USC - Dr. Leslie P Weiner, M.D.
Leslie P. Weiner, M.D. is Professor of Neurology and Molecular Microbiology and Immunology at the Keck School of Medicine of the University of Southern California. He also holds the Richard Angus Grant, Sr. Chair in Neurology. He received his B.A. at Wilkes College, Wilkes-Barre, Pennsylvania, and an M.D. from the University of Cincinnati College of Medicine in Ohio. He completed his internship at the State University of New York in Syracuse, New York, and his residency at The Johns Hopkins Hospital in Baltimore. He completed two fellowships: Medicine (Neurology) and Epidemiology at The Johns Hopkins University School of Medicine, and Immunology at the NIH Laboratory of Slow Virus Infections, NINDS at Laurel, Maryland. He was Associate Professor of Neurology at The Johns Hopkins University before he came to the USC School of Medicine in 1975 as Professor of Neurology and Microbiology. He was appointed Chairman of the Department of Neurology in 1979 and served until 2003. Dr. Weiner is actively involved in both laboratory and clinical research related to viral infections of the nervous system, autoimmune disorders, gene therapy, and of late, stem cells. Multiple sclerosis is his main area of interest. He has just completed a study of a T cell vaccine in secondary progressive MS. Dr. Weiner serves or has served on numerous scientific committees such as the John Douglas French Foundation for Alzheimer’s Disease, Starbright Foundation, Hereditary Disease Foundation, Amyotrophic Lateral Sclerosis Society of America, and the National Multiple Sclerosis Society. He has served on many NIH review committees. He is currently a member of the Research Programs Advisory Committee of the National Multiple Sclerosis Society, Chairman of the State of Connecticut Department of Public Health Stem Cell Research Peer Review Committee, a Director of the USC Center Without Walls of the Nancy Davis Race to Erase MS, and a select member of the Committee to Review the Adverse Effects of Vaccines sponsored by the Institute of Medicine of the National Academies.
Dr. Weiner was Editor-in-Chief of the book entitled Neural Stem Cells – Methods and Protocols, Second Edition, published by Humana Press in 2008.
He continues using stem cells to study the effect of inflammation on neural stem cell differentiation. His most recent effort is in restoring tolerance to myelin antigens in human and mouse models using gene therapy techniques. His other research interests are regeneration with stem cells, microfluidics and nanotechnology for the study of the nervous system, development of the EBV vaccine, immune response effect on oligodendrocyte progenitors, effect of MS treatments on neural stem cells, and seeking a viral cause of MS by studying human endogenous retroviruses.